Comment on “Extreme electric fields power catalysis in the active site of ketosteroid isomerase”

• Autores: Aditya Natarajan, Filip Yabukarski, Vandana Lamba
• Localización: Science, ISSN 0036-8075, Vol. 349, Nº 6251, 2015, págs. 936-936
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Fried et al. (Reports, 19 December 2014, p. 1510) demonstrated a strong correlation between reaction rate and the carbonyl stretching frequency of a product analog bound to ketosteroid isomerase oxyanion hole mutants and concluded that the active-site electric field provides 70% of catalysis. Alternative comparisons suggest a smaller contribution, relative to the corresponding solution reaction, and highlight the importance of atomic-level descriptions.