Response to Comment on “Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence”

• Autores: Zhiqiang Ma, Xiaolei Wang, Xiao Wang
• Localización: Science, ISSN 0036-8075, Vol. 349, Nº 6244, 2015, págs. 149-149
• Idioma: inglés
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• Resumen

  • Sherman et al. commented on the precedence of enantiodivergence, listing a number of congeneric natural products with opposite chirality. However, these “congeners” are not derived from enantiodivergent biosyntheses. Instead, they are antipodes arising from separate enantiomeric biosyntheses. A distinct feature of the biosynthesis of the cyclic pyrrole-imidazole dimers is the production of antipodal congeners without the corresponding enantiomers.