Catalytic asymmetric hydroamination of unactivated internal olefins to aliphatic amines

• Autores: Yang Yang, Shi-Liang Shi, Dawen Niu
• Localización: Science, ISSN 0036-8075, Vol. 349, Nº 6243, 2015, págs. 62-66
• Idioma: inglés
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• Resumen

  • Catalytic assembly of enantiopure aliphatic amines from abundant and readily available precursors has long been recognized as a paramount challenge in synthetic chemistry. Here, we describe a mild and general copper-catalyzed hydroamination that effectively converts unactivated internal olefins—an important yet unexploited class of abundant feedstock chemicals—into highly enantioenriched α-branched amines (≥96% enantiomeric excess) featuring two minimally differentiated aliphatic substituents. This method provides a powerful means to access a broad range of advanced, highly functionalized enantioenriched amines of interest in pharmaceutical research and other areas.