Regulatory T cells in skin facilitate epithelial stem cell differentiation

• Niwa Ali ^[1] ; Bahar Zirak ^[1] ; Robert Sanchez Rodriguez ^[1]
  1. [1] University of California
• Localización: Cell, ISSN 0092-8674, Vol. 169, Nº. 6, 2017, págs. 1119-1129
• Idioma: inglés
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• Resumen

  • The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of Tregs and HFSCs revealed that skin-resident Tregs preferentially express high levels of the Notch ligand family member, Jagged 1 (Jag1). Expression of Jag1 on Tregs facilitated HFSC function and efficient HF regeneration. Taken together, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the function of HFSCs.