A Case of Nonfatal Intoxication Associated with the Recreational use of Diphenidine
- Autores: Enrico Gerace, Elena Bovetto, Daniele Di Corcia, Marco Vincenti, Alberto Salomone
- Localización: Journal of forensic sciences, ISSN-e 1556-4029, ISSN 0022-1198, Vol. 62, Nº. 4, 2017, págs. 1107-1111
- Idioma: inglés
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Resumen
Diphenidine is a dissociative drug that shows several psychotropic effects including euphoria, shifts in perception of reality, hallucinations, and transient anterograde amnesia. In this study, a case of acute intoxication occurring after diphenidine intake is reported. A 30-year-old Caucasian male was hospitalized after he was found in a confused and agitated state and unable to communicate. The physical examination displayed tachycardia, miotic pupils, and increased both body temperature and respiratory rate. After a liquid–liquid extraction procedure, GC/MS analysis revealed the presence of diphenidine in plasma and urine at concentrations of 308 and 631 ng/mL, respectively. Methylphenidate and diclazepam were also detected in the plasma. The clinical progress of the patient was favorable, and his symptoms were cured with a symptomatic treatment. The combined circumstantial elements and toxicological results of the case reported revealed the occur- rence of an acute intoxication ascribable to the recreational abuse of diphenidine
