Resumen de Statin Use and 25-Hydroxyvitamin D Blood Level Response to Vitamin D Treatment of Older Adults
Heike A. Bischoff Ferrari, Karina Fischer, Endel J. Orav, Bess Dawson-Hughes, Ursina Meyer, Patricia O. Chocano Bedoya, Otto W. Meyer, Rahel Ernst, Simeon Schietzel, Franz Eberli, Hannes B. Staehelin, Gregor Freystätter, Susanne Roas, Robert Theiler, Andreas Egli, Nicholas M. Wilson
Objectives To determine whether statin use alters response of 25-hydroxyvitamin D (25(OH)D) level to vitamin D treatment.
Design Pooled analysis.
Setting Three double-blind randomized controlled trials that tested different doses of vitamin D.
Participants Participants of three trials (N = 646; mean age 76.3 ± 8.4, 65% female).
Measurements In all three trials, 25(OH)D status and statin use were assessed repeatedly over time (baseline, 6 and 12 months). Repeated-measures analysis was used to compare 25(OH)D response to vitamin D treatment at baseline and 6 and 12 months of statin users and nonusers, controlling for age, sex, body mass index, Charlson Comorbidity Index, vitamin D dose, trial, and season.
Results At baseline, 17.5% were statin users, and 65% were vitamin D deficient (25(OH)D < 20 ng/mL). Baseline 25(OH)D levels did not differ significantly between groups at baseline (18.8 for statin users, 17.2 ng/mL for nonusers, P = .07), but according to the longitudinal analyses, the total increase over 12 months in 25(OH)D concentration was significantly lower in statin users (13.1 ng/L) than nonusers (15.9 ng/mL; 21.4% difference; P = .009).
Conclusion Of persons aged 60 and older at high risk of vitamin D deficiency, statin users had a 21.4% smaller increase in 25(OH)D serum concentrations over time than nonusers, independent of vitamin D dose and other covariates.
