Role of Mass Spectrometry in Clinical Endocrinology

• Autores: Siva S. Ketha, Ravinder J. Singh, Hemamalini Ketha
• Localización: Endocrinology and metabolism clinics of North America, ISSN 0889-8529, Vol. 46, Nº. 3, 2017 (Ejemplar dedicado a: Biochemical and Imaging Diagnostics in Endocrinology), págs. 593-613
• Idioma: inglés
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• Resumen

  • The advent of mass spectrometry into the clinical laboratory has led to an improvement in clinical management of several endocrine diseases. Liquid chromatography tandem mass spectrometry found some of its first clinical applications in the diagnosis of inborn errors of metabolism, in quantitative steroid analysis, and in drug analysis laboratories. Mass spectrometry assays offer analytical sensitivity and specificity that is superior to immunoassays for many analytes. This article highlights several areas of clinical endocrinology that have witnessed the use of liquid chromatography tandem mass spectrometry to improve clinical outcomes.