A flexible parametric competing-risks model using a direct likelihood approach for the cause-specific cumulative incidence function

• Autores: S.I. Mozumder, M.J. Rutherford, Paul C. Lambert
• Localización: The Stata journal, ISSN 1536-867X, Vol. 17, Nº. 2, 2017, págs. 462-489
• Idioma: inglés
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• Resumen

  • Abstract. In competing-risks analysis, the cause-specific cumulative incidence function (CIF) is usually obtained in a modeling framework by either 1) transforming on all cause-specific hazards or 2) transforming by using a direct relationship with the subdistribution hazard function. We expand on current competing-risks methodology from within the flexible parametric survival modeling framework and focus on the second approach. This approach models all cause-specific CIFs simultaneously and is more useful for answering prognostic-related questions. We propose the direct flexible parametric survival modeling approach for the cause-specific CIF. This approach models the (log cumulative) baseline hazard without requiring numerical integration, which leads to benefits in computational time. It is also easy to make out-of-sample predictions to estimate more useful measures and incorporate alternative link functions, for example, logit links. To implement these methods, we introduce a new estimation command, stpm2cr, and demonstrate useful predictions from the model through an illustrative melanoma dataset.