TNP1 non-gene region and influences tumor characteristics by low-risk alleles in breast cancer

• Autores: Ali Hajizadeh, Massoud Houshmand, Mojgan Hosseini
• Localización: QUID: Investigación, Ciencia y Tecnología, ISSN-e 2462-9006, ISSN 1692-343X, Nº. Extra 1, 2017, págs. 669-673
• Idioma: inglés
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• Resumen

  • Breast cancer affected of multiple molecular by genetic or epigenetic.  Single nucleotide polymorphisms lead to genetic differences in breast cancer liability. The present study aimed at investigating the association of SNPs of two genes, PLSCR3 rs4784227 (phospholipid scramblase 3) Gene and TNP1 rs13387042 (transition protein 1) Gene with possibility of breast cancer in Iranian women. Two polymorphic variants are association with breast cancer, rs4784227 in Chromosome 17 and rs13387042 in Chromosome 2. First time, we evaluated these polymorphisms included 126 Patients and 160 controls of Iranian women. So DNA extracted of peripheral blood by Tetra-Primer ARMS –PCR technique also histochemical test HER2- , HER2+, ER-, ER+,  PR-  and PR+ upon breast tumor tissue patients. In the current study TNP1 GG gene and PLSCR3 CT  polymorphisms of SNPs variants had statistically significant association with breast cancer (44.375% , 11.9 ,frequency, Odd Ratio; 5.564, CI; 2.877-10.759, P value; 9.056e-08* * *) and (60.00%,27.77,frequency, Odd Ratio; 1.570, CI; 1.095-2.252, P value; 0.01391 *) respectively .On the other hands, number of total  test histochemical in PLSCR3 CC and TNP1 AG then AA were highest positive in  ER+ and PR+ .