Resumen de MGF (IGF-1) GG gene (RS6220) and low-risk in aa associated to breast cancer risk
Genetic factors and also as polymorphisms be associated to breast cancer. Breast cancer (BC) first of among death in women. This current study was determined the frequency MGF (IGF-1) Gene polymorphism in patients with breast cancer. The Mast cell growth factor gene polymorphism were associated with risk breast cancer. MGF is regulate to cell apoptosis, prolife, and differentiation. Present study to finds that MGF gene polymorphism has a relation with the risk of breast cancer. Two polymorphic variants (rs6220 and rs7136446) are associated to breast cancer. First time, we evaluated these study of 126 breast cancer and 160 controls Iranian women of peripheral blood, and then did extracted DNA using the genotyping technique by sequencing. In present study, MGF GG gene (rs6220) had significant association with breast cancer (37.3% frequency, Odd Retio;2.359, CI 0.208-3.621, P value; 0.001).
