Status of Therapeutic Gene Transfer to Treat Cardiovascular Disease in Dogs and Cats

• Autores: Meg M. Sleeper
• Localización: Veterinary Clinics of North America: Small Animal Practice: Small Animal Practice, ISSN-e 0195-5616, Vol. 47, Nº. 5, 2017, págs. 1113-1121
• Idioma: inglés
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• Resumen

  • Therapeutic gene delivery is used to treat inherited and acquired heart diseases by targeting a missing or defective gene (inherited disease) or modifying a deranged molecular pathway (acquired disease).

    Preclinical studies in large animal models of heart disease suggest various candidate transgenes may be effective in companion animals with naturally occurring heart disease.

    Multiple clinical trials have been completed or are underway in humans with heart disease with encouraging results.

    A clinical trial in Dobermans with dilated cardiomyopathy and congestive heart failure is planned to begin in 2017.