Resumen de Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients

H.T. Nacaroglu, O. Yigit, O.B. Gayret, M. Erol, O. Bumke, O. Zengi, M. Tasdemir, Zekeriya Taşdemir

• Background It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment.

  Objective This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma and to identify the biomarkers that play a role in this inflammation.

  Methods The study included patients aged 6–16 years who were diagnosed with asthma in the paediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey. Complete blood count parameters were compared between three groups: obese asthmatic (n = 43), obese non-asthmatic (n = 45), and non-obese non-asthmatic (control group, n = 30). Levels of high-sensitive CRP (hs-CRP), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), and matrix metalloproteinase-9 (MMP-9), and 25(OH)-vitamin D were compared between the groups.

  Results No statistically significant differences were observed in 25(OH)-vitamin D, NGAL, OPN, hs-CRP, and MMP-9 levels between groups. There was a statistically significant negative correlation between FEV1/FVC and NGAL and MMP-9.

  Conclusion This is the first study to investigate levels of hs-CRP, NGAL, OPN, MMP-9, and 25(OH)-vitamin D in obese asthmatic children. Larger studies with sputum and BAL examinations are required to determine the potential of biomarkers for identifying inflammation in obese asthmatic children.

  Abbreviations OPNosteopontin NGALneutrophil gelatinase-associated lipocalin MMP-9matrix metalloproteinase-9 BALbronchoalveolar lavage COPDchronic obstructive pulmonary disease hs-CRPhigh-sensitivity CRP GINAGlobal Initiative for Asthma