Epidemiology and pathophysiology of malignancy in common variable immunodeficiency?

• A.Tak Manesh ^[4] ; A.Aghamohammadi ^[1] ; G.Azizi ^[5] ; A.Heydari ^[1] ; F.Kiaee ^[1] ; M.Shaghaghi ^[1] ; N.Hossein-Khannazer ^[2] ; R.Yazdani ^[3] ; H.Abolhassani ^[1]
  1. [1] Tehran University of Medical Sciences

     Tehran University of Medical Sciences

     Irán

     
  2. [2] Shahid Beheshti University of Medical Sciences

     Shahid Beheshti University of Medical Sciences

     Irán

     
  3. [3] Isfahan University of Medical Sciences

     Isfahan University of Medical Sciences

     Irán

     
  4. [4] Member of RACGP, Melbourne, Australia
  5. [5] Alborz University of Medical Sciences, Karaj, Iran

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 45, Nº. 6, 2017, págs. 602-615
• Idioma: inglés
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• Resumen

  • Common variable immunodeficiency (CVID) is a diagnostic category of primary immunodeficiency (PID) which may present with heterogeneous disorders including recurrent infections, autoimmunity, granulomatous diseases, lymphoid and other types of malignancies. Generally, the incidence of malignancy in CVID patients is around 1.5–20.7% and usually occurs during the 4th–6th decade of life. Non-Hodgkin lymphoma is the most frequent malignancy, followed by epithelial tumours of stomach, breast, bladder and cervix. The exact pathological mechanisms for cancer development in CVID are not fully determined; however, several mechanisms including impaired genetic stability, genetic predisposition, immune dysregulation, impaired clearance of oncogenic viruses and bacterial infections, and iatrogenic causes have been proposed to contribute to the high susceptibility of these patients to malignancies.