Dr Svatikova and colleagues1 investigated acute cardiovascular responses in healthy adults 30 minutes after ingestion of an energy drink (containing 62 g of sugar, caffeine, and taurine) compared with a placebo drink (containing approximately 62 g of sugar but no caffeine or other stimulants). In addition, the authors investigated the cardiovascular response of energy drink consumption during mental and physical stress tests.
Dr Grasser and colleagues discuss the importance of longer postdrink blood pressure and heart rate observation periods and suggest that water would have been a more appropriate placebo drink.
First, with regard to duration of observation, our protocol was designed to follow closely the metabolism and bioavailability of caffeine. Oral absorption of caffeine from the intestinal tract is rapid and caffeine becomes completely bioavailable, reaching a peak plasma concentration 30 minutes after ingestion, whereas plasma half-life ranges from 3 to 10 hours.1
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