México
La fluorosis dental (FD) es la hipomineralización del esmalte dental causada por el aumento de la porosidad, cuya severidad se debe a una ingesta excesiva de flúor (F) con relación dosis-respuesta durante el desarrollo del esmalte. El objetivo del trabajo fue determinar la correlación de los polimorfismos rs810687 y rs411717 del gen colágeno tipo 1 alfa 2 (COL1A2 ) con FD en niños mexicanos de 10 a 12 años, utilizando el Índice de Dean para establecer el grado de FD y PCR-HRM para la genotipificación de los polimorfismos. Se incluyeron 100 niños de 10.9 ± 0.78 años; las frecuencias alélicas y genotípicas encontradas fueron: G = 52.5%, A = 47.5%, G/G = 27.5%, G/A = 49.8%, A/A = 22.5%, C = 63.3%, T = 36.5%, C/C = 40.3%, C/T = 46.3%, T/T = 13.3% de los polimorfismos rs810687 y rs411717, respectivamente, con un coeficiente de correlación de Pearson r = – 0.017 (p > 0.05) con FD. Los resultados mostraron que no existía correlación entre la FD y la presencia de los polimorfismos rs810687 y rs411717 del gen COL1A2.
Dental fluorosis (FD, for its achronym in spanish) is the hypomineralization of dental enamel caused by increased porosity, severity is due to an excessive intake of fluoride with a dose-response relationship during enamel development. The objective of this study was to determine correlation of rs810687 and rs411717 polymorphisms of (colageno tipo 1 alfa 2) COL1A2 gene with FD in Mexican children aged 10 to 12 years, using Dean Index to establish degree of FD and PCR-HRM for polymorphisms genotyping. We included 100 children of 10.9 ± 0.78 years; Allele and genotype frequencies found were: G = 52.5%, A = 47.5%, G/G = 27.5%, G/A = 49.8%, A/A = 22.5%, C = 63.3%, T = 36.5%, C/C = 40.3%, C/T = 46.3%, T/T = 13.3% of rs810687 and rs411717 polymorphisms respectively; with a Pearson correlation coefficient r = – 0.017 (p > 0.05) with FD. Results showed that there was no correlation between FD and presence of rs810687 and rs411717 polymorphisms of the COL1A2 gene.
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