A high-coverage Neandertal genome from Vindija Cave in Croatia

• Autores: Kay Prüfer, Cesare de Filippo, Steffi Grote
• Localización: Science, ISSN 0036-8075, Vol. 358, Nº 6363, 2017, págs. 655-658
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, to ~30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.