Prion-like domains program Ewing’s sarcoma

• Autores: James Shorter
• Localización: Cell, ISSN 0092-8674, Vol. 171, Nº. 1, 2017, págs. 30-31
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcriptional programs underlying Ewing’s sarcoma.