Guardians of the ERAD Galaxy

• Autores: Zhihao Sun, Jeffrey L. Brodsky
• Localización: Cell, ISSN 0092-8674, Vol. 171, Nº. 2, 2017, págs. 267-268
• Idioma: inglés
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• Resumen

  • The endoplasmic reticulum-associated degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al. report on a protein complex that acts as a guardian to protect these folding intermediates from being targeted for ERAD.