Stress Responses in Yeast

• Autores: Eulalia de Nadal, Francesc Posas Garriga
• Localización: Stress Response in Microbiology / José M. Requena Rolanía (aut.), 2012, págs. 257-285
• Idioma: inglés
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• Resumen

  • Adaptation to environmental stress requires changes in many aspects of cellular physiology essential for cell survival, such as gene expression, translation, metabolism, morphogenesis or cell cycle progression. Accordingly, the ability of eukaryotic cells to survive and thrive within adverse environments depends on rapid and robust stress responses. Stress-activated protein kinases (SAPKs) pathways are key elements on intracellular stress-signalling networks to respond and adapt to extracellular changes. In this review, we describe the different mechanisms used by model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, as well as the pathogenic fungus Candida albicans, to sense and transduce stress signals to SAPKs in response to osmo, heat and oxidative stresses. Moreover, other signalling pathways related to stress are discussed. Although much remains to be learned, studies from yeast have served to understand how stress signalling molecules adjust precise and efficient adaptation strategies to maximize cell survival in response to extracellular stimuli.