Fus zigzags its way to cross Beta

• Autores: Alex S. Holehouse, Rohit V. Pappu
• Localización: Cell, ISSN 0092-8674, Vol. 171, Nº. 3, 2017, págs. 499-500
• Idioma: inglés
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• Resumen

  • The low-complexity domain (LCD) of the FUS protein forms concentration-dependent assemblies, including liquid droplets and fibril-based hydrogels. The molecular structures of FUS within different assemblies and their functional relevance are subjects of intense debate. Murray et al. report an atomic-level structural model for FUS LCD fibrils that answers some questions and raises new ones.