Intracellular Fluid Mechanics: Coupling Cytoplasmic Flow with Active Cytoskeletal Gel

• Alex Mogilner ^[1] ; Angelika Manhart ^[2]
  1. [1] Courant Institute of Mathematical Sciences, New York University, EstadoCourant Institute of Mathematical Sciences, New York University, New York, Estados Unidos y Department of Biology, New York University, New York, Estados Unidos
  2. [2] Courant Institute of Mathematical Sciences, New York University, EstadoCourant Institute of Mathematical Sciences, New York University, New York, Estados Unidos
• Localización: Annual review of fluid mechanics, ISSN 0066-4189, Nº. 50, 2018, págs. 347-370
• Idioma: inglés
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• Resumen

  • The cell is a mechanical machine, and continuum mechanics of the fluid cytoplasm and the viscoelastic deforming cytoskeleton play key roles in cell physiology. We review mathematical models of intracellular fluid mechanics, from cytoplasmic fluid flows, to the flow of a viscous active cytoskeletal gel, to models of two-phase poroviscous flows, to poroelastic models. We discuss application of these models to cell biological phenomena, such as organelle positioning, blebbing, and cell motility. We also discuss challenges of understanding fluid mechanics on the cellular scale.