Cancer evolution: no room for negative selection

• Autores: Samuel F. Bakhoum, Dan A. Landau
• Localización: Cell, ISSN 0092-8674, Vol. 171, Nº. 5, 2017, págs. 987-989
• Idioma: inglés
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• Resumen

  • In this issue of Cell, Martincorena et al. and Campbell et al. interrogated the selection dynamics during tumor evolution using large-scale genomics datasets. They found that somatic mutations in cancer are largely neutral, highlighting a near-complete absence of negative selection. Neutral evolution enables tolerance of hypermutation, which defines a surprisingly large fraction of adult cancer.