Efecto de la Nicotinamida sobre la Pérdida de Fluidos en Cólera

• Autores: Fabián Mendoza, Renzo León
• Localización: Anales de la Facultad de Medicina, ISSN 1025-5583, ISSN-e 1609-9419, Vol. 58, Nº. 4, 1997, págs. 266-270
• Idioma: español
• Títulos paralelos:
  • The Efect of Nicotinamide on Cholera Fluid Losses
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• Resumen
  • español

    El cólera en nuestro país ha generado importantes problemas de salud pública. Actualmente es tratado recuperando el volumen perdido y eliminando el V. cholerae mas no bloqueando la acción de la toxina. Existen evidencias que la Nicotinamida actuaría sobre la toxina disminuyendo la secreción de agua y electrólitos. Se evaluó la capacidad de la Nicotinamida para reducir la pérdida de fluidos en conejos con cólera; utilizando un estudio experimental aleatorizado. Se administró nicotinamida a 10 conejos sanos, cuantificando sus excretas (g/día), pre y post administración para descartar efectos que alteren la interpretación de los resultados; no se halló diferencias estadísticamente significativas (p=0,3). Luego de 5 días, para asegurar la eliminación del fármaco, se infectó a los conejos dividiendolos en 2 grupos de 5; al presentarse la diarrea administramos Nicotinamida y placebo respectivamente, cuantificamos las deposiciones (g/día) hallando diferencia estadísticamente significativa (p<0,001); demostramos que la Nicotinamida disminuye la pérdida de fluidos en cólera; abriendo una nueva posibilidad terapéutica.

  • English

    Cholera has caused major public health problems in our country. Currently, therapeutic approach consist of both, recovering the lost volume and eliminating the microorganism; there isn´t, however, any therapeutic intervention that blockades the toxin action. There are evidences indicating that Nicotinamide could act on the toxin, decreasing water and electrolytes losses.In this work, Nicotinamide capacity to reduce fluids losses in Cholera-infected rabbits was analized through a randomized experimental study. Ten previously healthty rabbits received Nicotinamide; mass of stools (g/day) before and after Nicotinamide administration were assessed to rule out any side effects which can alter the results. There were no significant differences in the mass of stools (g/day) before and after Nicotinamide administration (p=0.3). Rabbits were infected with V. cholerae 5 days later (to assure the elimination of nicotinamide); then were divided in two groups (A and B), and five randomizely assigned to each group. When diarrhea appeared, group A rabbits received Nicotinamide and group B rabbits received placebo. Mass of stools were quantified in both groups, showing a significant difference (p < 0.001).Our study demonstrates that Nicotinamide decreases fluids losses caused by cholera, and opens a new avenue of therapy.