"A brief outline is given of the measures taken in the eighteenth and nineteenth centuries to control some viral diseases. The contribution of M.W. Beijerinck to the concept of virus in 1898 as well as the reception of that concept among medical circles in the first decades of the 20th century are discussed. The 1930s were characterized by technical advances such as electrophoresis, ultra-centrifugation, and electron microscopy, which gave new insights into the concept of viruses. Cell culture marked the beginning of clinical virology in about 1950. In the 1970s, virus diagnostics began to be used in a timely manner for the management of the patient. Immunofluorescence, enzyme linked immunosorbent assays, and monoclonal antibodies enabled a rapid step forwards. From the 1980s onwards advances in molecular biology and the rise of the information technology
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