Immunomodulation of allergic response in children and adolescents: What we can learn from lymphatic filarial infection
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A.M. Aguiar-Santos [2] ; S. Montenegro [2] ; Z. Medeiros [2] ; A. Rocha [2] ; C.N.L.Morais [2] ; A.R.Silva [1] ; C.Bonfim [3] ; T.R.Costa [1] ; E.S.C. Sarinho [1]
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[1] Universidade Federal de Pernambuco
Universidade Federal de Pernambuco
Brasil
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[2] Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz (Fiocruz), Recife, PE, Brazil
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[3] Fundação Joaquim Nabuco (Fundaj), Recife, Brazil
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- Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 46, Nº. 2, 2018, págs. 167-174
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Background Although it is well known that allergic diseases involve a strong Th2 immune response, with production of high levels of specific IgE allergen, knowledge on the association between filarial infection and allergies, among paediatric patients is scarce.
Objective To evaluate the allergic response patterns in cases of filarial infection by comparing peripheral eosinophils, total IgE levels, immediate hypersensitivity and cytokine levels in children and adolescents in Brazil.
Methods This was an exploratory study with three groups: (I) with filarial infection and without allergic diseases; (II) without filarial infection and with allergic diseases; and (III) without filarial infection and without allergic diseases. The prick test and specific IgE tests for aeroallergens were performed using five antigens. Peripheral eosinophils and total IgE were also evaluated. IL-4 and IL-5 were determined using whole-blood culture stimulated by three antigens.
Results Eosinophilia and elevated levels of total IgE (≥400 IU/dl) were observed in all groups. The prick test was positive in 56.6% of the cases. Group I presented hypersensitive responses similar to the allergic disease groups. In the whole-blood culture stimulated by Dermatophagoides pteronyssinus, average IL-4 production did not differ significantly among the groups, but IL5 production resulting from stimulation was greater in the allergic disease groups (p < 0.05).
Conclusions The allergic response pattern in group with filarial infection was similar to that of the groups with and without allergic diseases, but the response to IL-5 in the culture stimulated by D. pteronyssinus was an exclusive characteristic of the allergic group.
