Resumen de Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell
Jitin Singla, Kyle M. McClary, Kate L. White
The construction of a predictive model of an entire eukaryotic cell that describes its dynamic structure from atomic to cellular scales is a grand challenge at the intersection of biology, chemistry, physics, and computer science. Having such a model will open new dimensions in biological research and accelerate healthcare advancements. Developing the necessary experimental and modeling methods presents abundant opportunities for a community effort to realize this goal. Here, we present a vision for creation of a spatiotemporal multi-scale model of the pancreatic β–cell, a relevant target for understanding and modulating the pathogenesis of diabetes.
