Beyond an oncogene, Lin28 is a master regulator of cancer progression

• Xuefei Wang ^[1] ; Mingjiao Weng ^[1] ; Yinji Jin ^[1] ; Weiwei Yang ^[1] ; Xin Wang ^[1] ; Di Wu ^[2] ; Tianzhen Wang ^[1] ; Xiaobo Li ^[1]
  1. [1] Harbin Medical University

     Harbin Medical University

     China

     
  2. [2] First Affiliated Hospital of Harbin Medical University

     First Affiliated Hospital of Harbin Medical University

     China

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 33, Nº. 4, 2018, págs. 327-334
• Idioma: inglés
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• Resumen

  • The RNA binding protein Lin28 is increased in most human malignancies, and elevated Lin28 is a biomarker for poor prognosis and contributes to cancer progression. Lin28 functions as a master oncogene and is involved in almost all hallmarks of cancer. In this review, we summarize the aberrant molecular expression mechanisms and pathological roles of Lin28 in cancer progression. Moreover, we elaborate on the established molecular mechanisms, from the transcriptional level to the post-transcriptional and translational levels, by which Lin28 regulates cancer progression.