Now Joseph Pickrell at Columbia University in New York and his team have analyzed human genome sequences to spot gene variants that are becoming rarer. One variant of a gene called CHRNA3, is associated with heavier smoking in those that smoke, raising their risk of a smoking-related death. Comparing people over the age of 80 with people over the age of 60, Pickrell estimates that the variant has declined by 1 percent between generations. However, his team wasn't able to prove this, as they didn't have any genomic data from people under the age of 40.
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