Dangerous entrapment for NRF2

• Autores: Vera Gorbunova, Sarallah Rezazadeh, Andrei Seluanov
• Localización: Cell, ISSN 0092-8674, Vol. 165, Nº. 6, 2016, págs. 1312-1313
• Idioma: inglés
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• Resumen

  • Progerin, a mutated lamin A, causes the severe premature-aging syndrome Hutchinson-Gilford progeria (HGPS). Kubben et al. present a driving mechanism for HGPS involving trapping of NRF2 at the nuclear periphery by progerin. This local restriction results in impaired NRF2 signaling and chronic oxidative stress.