Component-resolved diagnosis in hymenoptera allergy

• D. Antolín-Amérigo ^[1] ; B. Ruiz-León ^[2] ; E. Boni ^[7] ; T. Alfaya-Arias ^[3] ; M. Álvarez-Mon ^[1] ; J. Barbarroja-Escudero ^[1] ; D. González-de-Olano ^[4] ; C. Moreno-Aguilar ^[2] ; M. Rodríguez-Rodríguez ^[1] ; M.J. Sánchez-González ^[1] ; L. Sánchez-Morillas ^[5] ; A. Vega-Castro ^[6]
  1. [1] Hospital Universitario Príncipe de Asturias

     Hospital Universitario Príncipe de Asturias

     Alcalá de Henares, España

     
  2. [2] Hospital Universitario Reina Sofia

     Hospital Universitario Reina Sofia

     Cordoba, España

     
  3. [3] Hospital General de Ciudad Real

     Hospital General de Ciudad Real

     Ciudad Real, España

     
  4. [4] Hospital Ramón y Cajal

     Hospital Ramón y Cajal

     Madrid, España

     
  5. [5] Hospital Clínico San Carlos de Madrid

     Hospital Clínico San Carlos de Madrid

     Madrid, España

     
  6. [6] Hospital Universitario de Guadalajara

     Hospital Universitario de Guadalajara

     Guadalajara, España

     
  7. [7] Hospital Santo Spirito, Italia

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 46, Nº. 3, 2018, págs. 253-262
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api m1), hyaluronidase (Api m2) and melittin (Api m4). Additionally, in recent years, new allergens of Vespula vulgaris have been identified and include phospholipase A1 (Ves v1), hyaluronidase (Ves v2) and antigen 5 (Ves v5). Polistes species are becoming an increasing cause of allergy in Europe, although only few allergens have been identified in this venom.

    In this review, we evaluate the current knowledge about molecular diagnosis in hymenoptera venom allergy.