The roles of toll like receptor 3, 7 and 8 in allergic rhinitis pathogenesis
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[1] Rafsanjan University of Medical Sciences
Rafsanjan University of Medical Sciences
Irán
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[2] Kerman University of Medical Sciences
Kerman University of Medical Sciences
Irán
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- Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 46, Nº. 5, 2018, págs. 503-507
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Allergic rhinitis, as an allergic and nasal hypersensitivity disease, is associated with the inflammation of nasal mucosa. It appears that innate immune receptors are the important risk factors in the pathogenesis of the inflammatory disease. Toll-like receptors (TLRs) are the most important receptors of innate immunity; their crucial roles in the recognition of allergens and subsequently pathogenesis of allergic diseases have been evaluated recently. TLR3, 7 and 8 are the intracellular members of the innate immune receptors and recognize intracellular single and double strand RNAs. This review article collected the investigations regarding the roles of TLR3, 7 and 8 in the allergic rhinitis pathogenesis.
