Mechanism of Virus Inactivation by Cold Atmospheric-Pressure Plasma and Plasma-Activated Water

• Li Guo ^[1] ; Ruobing Xu ^[1] ; Lu Gou ^[1] ; Zhichao Liu ^[1] ; Yiming Zhao ^[1] ; Dingxin Liu ^[1] ; Lei Zhang ^[1] ; Hailan Chen ^[2] ; Michael G. Kong ^[1]
  1. [1] Xi'an Jiaotong University

     Xi'an Jiaotong University

     China

     
  2. [2] Old Dominion University

     Old Dominion University

     Estados Unidos

     
• Localización: Applied and Environmental Microbiology, ISSN 0099-2240, Vol. 84, Nº 17, 2018
• Idioma: inglés
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• Resumen

  • Contamination with pathogenic and infectious viruses severely threatens human health and animal husbandry. Current methods for disinfection have different disadvantages, such as inconvenience and contamination of disinfection by-products (e.g., chlorine disinfection). In this study, atmospheric surface plasma in argon mixed with air and plasma-activated water was found to efficiently inactivate bacteriophages, and plasma-activated water still had strong antiviral activity after prolonged storage. Furthermore, it was shown that bacteriophage inactivation was associated with damage to nucleic acids and proteins by singlet oxygen. An understanding of the biological effects of plasma-based treatment is useful to inform the development of plasma into a novel disinfecting strategy with convenience and no by-product.