The molecular harbingers of early mammalian embryo patterning

• Autores: Jun Wu, Juan Carlos Izpisúa Belmonte
• Localización: Cell, ISSN 0092-8674, Vol. 165, Nº. 1, 2016, págs. 13-15
• Idioma: inglés
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• Resumen

  • Random or not, the mechanisms at play during the first cell-fate determination in mammalian embryos have been debated for years. Studies by Goolam et al. and White et al. shed new light on the molecular mechanisms underlying the intrinsic biases that lead to non-random lineage segregation in early mammalian development.