Dosimetry study of 18F-FMISO + PET/CT hypoxia imaging guidance on intensity-modulated radiation therapy for non-small cell lung cancer

H. Li; D. Xu; X. Han; Q. Ruan; X. Zhang; Y. Mi; M. Dong; S. Guo; Y. Lin; B. Wang; Guowen Li

Ayuda

Dosimetry study of 18F-FMISO + PET/CT hypoxia imaging guidance on intensity-modulated radiation therapy for non-small cell lung cancer

H. Li ^[1] ; D. Xu ^[1] ; X. Han ^[1] ; Q. Ruan ^[1] ; X. Zhang ^[1] ; Y. Mi ^[1] ; M. Dong ^[1] ; S. Guo ^[2] ; Y. Lin ^[1] ; B. Wang ^[1] ; G. Li ^[1]
1. [1] First Affiliated Hospital of Zhengzhou University
  
  First Affiliated Hospital of Zhengzhou University
  
  China
2. [2] Zhengzhou Central Hospital
  
  Zhengzhou Central Hospital
  
  China
Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 20, Nº. 10 (October 2018), 2018, págs. 1329-1336
Idioma: inglés
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Resumen
- Objectives This study was to evaluate the feasibility of simultaneous integrated boost on tumor hypoxia area by studying the dosimetric change of hypoxia imaging guidance on intensity-modulated radiation therapy for non-small cell lung cancer (NSCLC).
  
  Methods Five NSCLC patients with large hypoxic volume participated in this study. FDG PET/CT images were fused with CT localization images to delineate gross tumor volume. FMISO PET/CT images were fused with CT localization images to delineate hypoxic biological target volume (BTV) (tissue maximum ratio ≥ 1.3) by threshold. BTV was irradiated with 72, 78 and 84 Gy, respectively, 30 times. The dosimetry differences were compared in target volume and organ at risk between simultaneous integrated boost plans and conventional radiotherapy plans.
  
  Results Dosages on BTV of NSCLC hypoxic area were increased to 72, 78 and 84 Gy, respectively, by simultaneous integrated boost intensity-modulated radiation therapy. There was no obvious difference in dosage distributions on original target volume compared with those in conventional radiotherapy. Dosages on main organ at risk in chest met the dosimetric constraint, and there was no significant difference compared with those in conventional radiotherapy.
  
  Conclusion It is feasible in dosiology that the dosages in NSCLC hypoxic area were added to 72, 78 and 84 Gy by simultaneous integrated boost with the guidance of 18F-FMISO PET/CT.