Drugs that change the chemistry and structure of the brain could boost the intelligence of people with Down's syndrome. Several compounds have improved memory and learning in a mouse version of the condition, suggesting that its cognitive effects can be changed. Until recently, this idea was unthinkable, says Mara Dierssen at the Centre for Genomic Regulation in Barcelona, Spain. Such efforts to improve brain function are controversial, with some activists saying people should be valued as they are But some families have decided to give their children drugs like Prozac that have not yet been thoroughly tested for Down's syndrome
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