Vector without Virus.

• Autores: Charles Q. Choi
• Localización: Scientific American, ISSN 0036-8733, Vol. 292, Nº. 3, 2005, págs. 30-30
• Idioma: inglés
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• Resumen

  • This article reports on research into delivering JOURes into human cells. To deliver JOURes into cells, scientists rely on engineered viruses, but these germs often provoke immune responses and make them potentially lethal. New silica nanoparticles with organic components may prove effective nonviral DNA carriers. Chemists at the University at Buffalo found that the electric charge on these nanoparticles held and compacted the DNA, protecting it from enzymatic digestion in cells. The organic components also render normally rigid silica nanoparticles more flexible and capable of releasing encapsulated biomolecules and might make the nanoparticles safely biodegradable as well.