The triumvirate of beta-cell regeneration: solutions and bottlenecks to curing diabetes

• Autores: Sumeet P. Singh, Nikolay Ninov
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 62, Nº. Extra 6-8, 2018 (Ejemplar dedicado a: Regeneration), págs. 453-464
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • On 11 January 1922 insulin injection was used for the first time in the treatment of diabetes. Even today, daily insulin injections are the life-saving treatment for patients with Type 1 diabetes and advanced Type 2 diabetes. However, insulin injections often fail to achieve full glucose control, which in the long-term leads to multiple complications and mortality. Beta-cells, the natural producers and secretors of insulin, remain the gold-standard in regulating blood glucose levels. In this review, we focus on three strategies aiming at counteracting beta-cell loss in order to gain insulin independence: replacement, replication and protection. The three approaches, together termed as the triumvirate of beta-cell regeneration, may constitute the basis for a future cure for diabetes.