Custom-made oocytes to clone non-human primates

• Autores: Jose B. Cibelli, John B. Gurdon
• Localización: Cell, ISSN 0092-8674, Vol. 172, Nº. 4, 2018, págs. 647-649
• Idioma: inglés
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• Resumen

  • In this issue of Cell, Liu et al. (2018) report the birth of two healthy cloned macaque monkeys using fetal fibroblasts. By artificially enhancing the arsenal of epigenetic modifiers in the oocyte, the authors overcome the earliest roadblocks that take place during somatic cell nuclear transfer (SCNT).