Resumen de Hepatoprotective Effects of the Honey of Apis cerana Fabriciuson Bromobenzene‐Induced Liver Damage in Mice
Haoan Zhao, Ni Cheng, Liangliang He, Guoxia Peng, Qingqing Liu, Tianchen Ma, Wei Cao
Apis ceranahoney (honey of Apis cerana Fabricius), widely distributed in the mountain areas of East Asia, has not been studied fully. The hepatoprotective activity of A. ceranahoney was evaluated against bromobenzene‐induced liver damage in mice. In high dose, A. ceranahoney can significantly alleviate liver injury, as is indicated by the depressed levels of serum alanine aminotransferase (ALT) (59.13%) and aspartate aminotransferase (AST) (79.71%), the inhibited malondialdehyde (MDA) content (63.30%), the elevated activities of superoxide dismutase (SOD) (73.12%) and glutathione‐Px (57.24%), and the decreased expression of Transforming growth factor β1 (51.83%) induced by bromobenzene (P< 0.05). The quantitative analysis of twelve major constituents (1 to 12) of A. ceranahoney was executed by high performance liquid chromatography‐diode array detector. The results indicate that treatment with A. ceranahoney can prevent bromobenzene‐induced hepatic damage in mice. Polyphenols might be the bioactive substances attributed to its antioxidant properties and intervention of oxidative stress.
