Resumen de Effect of Emulsification Method and Particle Size on the Rate of in vivoOral Bioavailability of Kenaf (Hibiscus cannabinusL.) Seed Oil
Ai Mun Cheong, Chin P. Tan, Kar Lin Nyam
Kenaf (Hibiscus cannabinusL.) seed oil‐in‐water nanoemulsions stabilized by complexation of beta‐cyclodextrin with sodium caseinate and Tween 20 have been shown to have higher bioaccessibility of vitamin E and total phenolic content than nonemulsified kenaf seed oil in the previous in vitrogastrointestinal digestion study. However, its oral bioavailability was unknown. Therefore, the aim of this study was to evaluate the rate of in vivooral bioavailability of kenaf seed oil‐in‐water nanoemulsions in comparison with nonemulsified kenaf seed oil and kenaf seed oil macroemulsions during the 180 min of gastrointestinal digestion. Kenaf seed oil macroemulsions were produced by using conventional method. Kenaf seed oil‐in‐water nanoemulsions had shown improvement in the rate of absorption. At 180 min of digestion time, the total α‐tocopherol bioavailability of kenaf seed oil nanoemulsions was increased by 1.7‐ and 1.4‐fold, compared to kenaf seed oil and macroemulsion, respectively. Kenaf seed oil‐in‐water nanoemulsions were stable in considerably wide range of pH (>5 and <3), suggesting that it can be fortified into beverages within this pH range The production of kenaf seed oil‐in‐water nanoemulsions had provided a delivery system to encapsulate the kenaf seed oil, as well as enhanced the bioaccessibility and bioavailability of kenaf seed oil. Therefore, kenaf seed oil‐in‐water nanoemulsions exhibit a great potential application in nutraceutical fields.
