Multi-regional sequencing elucidates the evolution of clear cell renal cell carcinoma

• Autores: Christopher J. Ricketts, W. M. Linehan
• Localización: Cell, ISSN 0092-8674, Vol. 173, Nº. 3, 2018, págs. 540-548
• Idioma: inglés
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• Resumen

  • Extensive multi-regional whole-genome and -exome sequencing performed in tumors from patients with localized, as well as metastatic, clear cell renal cell carcinoma provides a comprehensive description of the tumor origin, intratumoral heterogeneity, evolution, and route to metastasis, laying the foundation for the development of precision clinical management.