Better together: a hybrid amyloid signals necroptosis

• Autores: Dan Li, Cong Liu
• Localización: Cell, ISSN 0092-8674, Vol. 173, Nº. 5, 2018, págs. 1068-1070
• Idioma: inglés
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• Resumen

  • A new solid-state NMR study determines the high-resolution hetero-amyloid structure of the RIPK1-RIPK3 signaling complex that is involved in mediating necroptosis. The structure demonstrates specific formation of hetero-amyloids over homo-amyloids and the structural basis for a functional amyloid to act as a platform to recruit and activate downstream partners in intracellular signaling.