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Resumen de Hidden switches in the mind.

Eric J. Nestler

  • The article discusses how experience may contribute to mental illness by causing epigenetic changes, which result when genes are switched on or off without being altered themselves. According to the author, research has suggested that experiences can contribute to mental illness by adding or removing genetic marks on chromosomes, which are particular chemical tags that influence gene activity without changing the information encoded in the genes. Topics include an overview of studies in mice demonstrating the role of long-lasting epigenetic modifications in addiction and depression disorders and the effect that epigenetic changes have on maternal behavior in ways that reproduce the same behavior in their offspring. INSETS: Genetics vs. Epigenetics;Epigenetics of Addiction;My Mother, Myself.


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