Douglas J. Mahoney, David F. Stojdl, Gordon Laird
The article discusses the use of engineered viruses to treat cancer called oncolytic virotherapy. Topics include examples of cervical cancer patients in Italy treated with the rabies vaccine in the early 1900s, a clinical drug trial of the oncolytic virus T-VEC that both destroys metastatic melanoma (skin cancer) cells directly and induces the production of an immune protein called GM-CSF, the appeal of viruses for cancer therapy, and ways researchers are enhancing virotherapy.
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