The author discusses the potential health and longevity benefits of calorie restriction, focusing on intermittent fasting. Topics include the history of fasting and calorie restriction as a medical treatment, research concerning calorie restriction in rats and mice, and brain-derived neurotrophic factor proteins. According to the author, intermittent fasting may increase the human body's response to insulin and boost cellular defenses, but the evidence supporting the health benefits of fasting for humans is ambiguous as of January, 2013.
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