The article looks at research into the role of oxidative damage caused by free radicals in aging and the effectiveness of antioxidant vitamins to prevent age-related diseases. In a study of Caenorhabditis elegans worms genetically engineered to stop producing antioxidant enzymes, researchers found that the worms exhibited oxidative damage, but not early death. Another study discovered that naked mole rats, a species with a long life span, showed lower natural antioxidant levels and higher oxidative damage of tissues than other rodents. Other topics include the effects of superoxide radicals on aging, beneficial effects of environmental stress, and the potential health risks of antioxidant supplements. INSETS: When Vitamins Kill;Insight from Mutant Worms.
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