The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis

• Yoku Hayakawa ^[1] ; Timothy C Wang ^[2]
  1. [1] University of Tokyo

     University of Tokyo

     Japón

     
  2. [2] Columbia University

     Columbia University

     Estados Unidos

     
• Localización: Cell, ISSN 0092-8674, Vol. 174, Nº. 2, 2018, págs. 251-253
• Idioma: inglés
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• Resumen

  • The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling