Early Hits and Long-Term Consequences: Tracking the Lasting Impact of Prenatal Smoke Exposure on Telomere Length in Children.

• Autores: Katherine P. Theall, Sarah McKasson, Emily Mabile, Lauren F. Dunaway, Stacy S. Drury
• Localización: American journal of public health, ISSN 0090-0036, Vol. 103, Nº. 0, 2013, págs. 133-135
• Idioma: inglés
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• Resumen

  • We examined the association between telomere length and prenatal tobacco exposure (PTE) in 104 children aged 4 to 14 years. Salivary telomere length (STL) was determined from salivary DNA using quantitative polymerase chain reaction. Of the children, 18% had maternal reported PTE. Mean STL was significantly lower among children with PTE (6.4 vs 7.5, P < .05). Findings extend the literature demonstrating the negative long-term effects of PTE to include a cellular marker of aging linked to multiple negative health outcomes. [ABSTRACT FROM AUTHOR]