The role of lamin A/C in mesenchymal stem cell differentiation

• Bo Zhang ^[1] ; Yang Yang ^[1] ; Reziwan Keyimu ^[1] ; Jin Hao ^[2] ; Zhihe Zhao ^[1] ; Rui Ye ^[1]
  1. [1] State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology. Sichuan University, China
  2. [2] Program in Biological Sciences in Dental Medicine. Harvard School of Dental Medicine, Estados Unidos
• Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 75, Nº. 1 (February), 2019, págs. 11-18
• Idioma: inglés
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• Resumen

  • Lamin A/C is the major architectural protein of cell nucleus in charge of the nuclear mechanosensing. By integrating extracellular mechanical and biochemical signals, lamin A/C regulates multiple intracellular events including mesenchymal stem cell (MSC) fate determination. Herein, we review the recent findings about the effects and mechanisms of lamin A/C in governing MSC lineage commitment, with a special focus on osteogenesis and adipogenesis. Better understanding of MSC differentiation regulated by lamin A/C could provide insights into pathogenesis of age-related osteoporosis.