PP1 Phosphatase Complexes: Undruggable No Longer

• Paola Vagnarelli ^[1] ; Dario R. Alessi ^[2]
  1. [1] Brunel University London

     Brunel University London

     Hillingdon, Reino Unido

     
  2. [2] University of Dundee

     University of Dundee

     Reino Unido

     
• Localización: Cell, ISSN 0092-8674, Vol. 174, Nº. 5, 2018, págs. 1049-1051
• Idioma: inglés
• Enlaces
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• Resumen

  • The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington’s disease.